Matteo Berrettini secured his place in the US Open quarter-finals for a second successive year with a five-set win over unseeded Alejandro Davidovich Fokina on Louis Armstrong Stadium.
Italian Berrettini, who reach the semi-finals in 2019, overcame the Spaniard 3-6 7-6 (7-2) 6-3 4-6 6-2 in New York.
Davidovich Fokina suffered a knee injury when trailing 4-2 in the fifth set and could not fight back.
Berrettini faces either Casper Ruud or Corentin Moutet in the last eight.