Kyle Edmund, Aljaz Bedene and Cameron Norrie will carry British hopes on a busy third day at the US Open after rain washed out much of day two.
Edmund plays American Steve Johnson in the fifth match on Louis Armstrong Stadium at about 23:00 BST.
Norrie faces Spanish 12th seed Pablo Carreno Busta at a similar time, while Bedene takes on Russian Andrey Rublev at around 19:00.
Maria Sharapova, Venus Williams and Jo-Wilfried Tsonga are also in action.
Edmund, Bedene and Norrie are the last remaining Britons in the singles draws after defeats for Johanna Konta and Heather Watson on Monday.