With none of the sport's 'big three' in the semi-finals, the US Open men's singles is wide open in New York.
For the first time since 2016, a Grand Slam will not be won by Roger Federer, Rafael Nadal or Novak Djokovic.
German fifth seed Alexander Zverev takes on Spanish 20th seed Pablo Carreno Busta in Friday's first semi-final at 21:00 BST, with Austrian second seed Dominic Thiem facing Russian third seed Daniil Medvedev afterwards.
Switzerland's Stan Wawrinka was the last man other than Federer, Nadal and Djokovic to secure a Grand Slam title when he triumphed at the 2016 US Open.