British number one Kyle Edmund hopes to join compatriots Johanna Konta and Dan Evans in the second round of the US Open when he takes on Spaniard Pablo Andujar on Tuesday.
The 30th seed reached the fourth round in 2016 but lost to Italian Paolo Lorenzi in round one last year.
Edmund, 24, has won three of his last six tour matches since being knocked out in the second round at Wimbledon.
Konta beat Daria Kasatkina, while Evans overcame Adrian Mannarino on Monday.
Elsewhere, 18-time Grand Slam champion Rafael Nadal kicks off the evening session on Arthur Ashe, taking on Australian world number 60 John Millman, who shocked Roger Federer in the fourth round last year.