Johanna Konta and Dan Evans - Britain's remaining players in the US Open singles - face first-time opponents in the second round on Wednesday.
British number one Konta, who opened with a win over Daria Kasatkina, faces Margarita Gasparyan (16:00 BST).
British number two Evans has a tough test against world number 27 Lucas Pouille in the men's draw.
Defending men's champion Novak Djokovic is up against Juan Ignacio Londero.
Before that five-time champion Roger Federer, who last won the title in 2008, plays Bosnia-Herzegovina's Damir Dzumhur in one of the two early matches inside Arthur Ashe Stadium.