Former champions Roger Federer, Novak Djokovic, Maria Sharapova and Angelique Kerber will be in second-round action on day four of the US Open.
Five-time winner Federer, 37, plays France's Benoit Paire on Arthur Ashe Stadium, after fourth seed Kerber's match against Sweden's Johanna Larsson.
Djokovic and Sharapova play in the night session on Ashe, from 00:00 BST.
The Serb, a two-time champion, faces American Tennys Sandgren, while 2006 winner Sharapova plays Sorana Cirstea.
Second seed Caroline Wozniacki is another player with experience of reaching the final at Flushing Meadows, twice finishing as a runner-up.
The second seed, who said she kept cool by pretending to be "on the beach with a margarita in hand" after seeing off Sam Stosur in the first round, faces Ukraine's Lesia Tsurenko last on the Louis Armstrong Stadium.