The only Grand Slam champions left in the women's draw will meet when Venus Williams plays Petra Kvitova in the US Open quarter-finals on day nine.
American ninth seed Williams and Czech 13th seed Kvitova open the night session at 00:00 BST on Wednesday.
Williams is the only former US Open winner in the last eight and looking for her first major win in nine years.
"I'll take any advantage I can get, let's face it," said the 37-year-old, who was champion in 2000 and 2001.
"But at the end of the day when I go out there and someone's across the net from me, they're playing well.