Britain's Dan Evans is out of the Paris Masters following a second round defeat by world number five Stefanos Tsitsipas, while compatriot Jack Draper lost to American Frances Tiafoe.
Draper, 20, fell to a 6-3 7-5 loss against US Open semi-finalist Tiafoe.
Cameron Norrie, the last Briton remaining in the draw, plays France's Corentin Moutet in his second round match in Paris later on Wednesday.
The Paris Masters is the final regular ATP Tour event of the season, before the ATP finals get under way in Turin on 13 November.
Tsitsipas, 24, recorded breaks of serve early in both sets against Evans, ranked 27th, and awaits the winner of Norrie's meeting with Moutet in the third round.