Cameron Norrie became the final British singles player to fall at the US Open as 24-time Grand Slam champion Novak Djokovic battled through injury to reach the fourth round.
Norrie, 30, has now lost all seven of his meetings with the 38-year-old Serb following a 6-4 6-7 (3-7) 6-2 6-3 defeat in New York.
Djokovic, who is bidding for a standalone record 25th major title, struggled with a lower back injury in the opening set and needed a medical time-out off the court.
The four-time US Open champion asked for more treatment early in the second set.