Nick Kyrgios says the United States Tennis Association is being "selfish" by intending to stage the US Open from 31 August.
On Tuesday, organisers are expected to set out how the Grand Slam will go ahead behind closed doors.
Novak Djokovic, Rafael Nadal and Simona Halep have all voiced concerns over the plans with New York still recording hundreds of coronavirus cases per day.
Kyrgios said he will get his "hazmat suit ready" for when he travels.
"People that live in the US of course are pushing the Open to go ahead - selfish," the Australian world number 40 posted on Twitter.