Britain's Cameron Norrie fell just short of a maiden ATP title for the second time in three weeks, as he was beaten 6-3 6-3 in the Lyon Open final by Stefanos Tsitsipas.
The Greek world number five, 22, took just 70 minutes to claim his seventh career title and second of the year.
He broke the British number two, ranked 44 places below him, twice in the second set to seal victory.
Tsitsipas has won the most matches on the ATP Tour in 2021 with 33.
In April, he won his first Masters 1,000 title at the Monte Carlo Masters and then reached the final in Barcelona, losing to Rafael Nadal after holding a championship point.