Home favourite Caroline Garcia became the highest-ranked women's player to exit the French Open so far with a second-round loss to Anna Blinkova.
Fifth seed Garcia saved eight match points before succumbing to a 4-6 6-3 7-5 defeat by the Russian.
Garcia is the 16th seed to exit the women's draw as the second round got under way on Wednesday.
It came after former champion Jelena Ostapenko suffered a shock defeat by tournament debutant Peyton Stearns.
Latvian 17th seed Ostapenko, the 2017 champion at Roland Garros, lost 6-3 1-6 6-2 to the American.
Stearns, 21, is playing in her first overseas Grand Slam after making her major debut at last year's US Open.