Novak Djokovic has been drawn in the same half of the French Open men's singles draw as Carlos Alcaraz, meaning the pair could meet in the semi-finals.
World number one Alcaraz, playing his first major as a Grand Slam champion, starts against a qualifier.
Djokovic is seeded third as he goes for a record 23rd men's major title and plays American Aleksandar Kovacevic.
Cameron Norrie, one of only three British players in the singles, starts against France's Benoit Paire.
Former world number one Andy Murray withdrew last week to focus on the upcoming grass-court season.