Britain's Johanna Konta was beaten 6-4 7-6 (7-1) by world number two Simona Halep to exit the Cincinnati Open in the quarter-finals.
Konta, who beat the Romanian in the last eight of Wimbledon, took an early lead in a first set that featured five breaks of serve before Halep triumphed.
The Romanian went 4-1 up in the second and, despite Konta saving five match points, took the match on a tie-break.
In the men's draw, Nick Kyrgios beat Spaniard Rafael Nadal 6-2 7-5.
Australian Kyrgios will play Spain's David Ferrer, who beat Dominic Thiem 6-3 6-3 in the semi-finals, while the other last four match will see Grigor Dimitrov play John Isner.