Great Britain's Katie Boulter and Cameron Norrie both suffered straight sets defeats at the China Open.
British number two Boulter suffered a comprehensive 6-1 6-3 loss against Wimbledon and US Open finalist Amanda Anisimova, having beaten her American compatriot Hailey Baptiste in round one.
In the men's draw, Norrie is also out after losing to eighth-seeded Daniil Medvedev in the first round.
He beat the Russian at the French Open earlier this year, but fell short on the rematch, losing 6-3 6-4 in Beijing.
Last week, Boulter helped Great Britain to reach the semi-finals of the Billie Jean King Cup with a statement win over Japan's Moyuka Uchijima, a welcome return to form after her Wimbledon ended with a second-round defeat to lucky loser Solana Sierra and she failed to progress from round one at the US Open.