The third-seeded Lady Vols had been 57-0 at home with most of those victories coming under late Hall of Fame coach Pat Summitt, who led the team to eight national championships. It's the second straight season that Tennessee lost in the second round of the NCAAs and will miss the Sweet 16 in back-to-back seasons for the first time in the program's 37-year tournament history.
Oregon State (26-7) advanced to the regional semifinals for the third straight year.
The Lady Vols (24-8) and Beavers played a close game befitting of two teams separated by only spot in the AP poll entering the tournament.