TCU took a five-point lead against No. 12 Texas Tech into halftime Saturday afternoon at United Spirit Arena in Lubbock.
It's the regular-season finale for both teams. The Big 12 Conference tournament begins Wednesday in Kansas City, Mo.
The Horned Frogs (21-9, 9-8 in the Big 12) will open against Kansas State at 11:30 a.m. Thursday regardless of the outcome of Saturday's game.
TCU led 40-35 at the half. The last time TCU beat a ranked team on the road was at Hawaii in January 1998.
Desmond Bane leads the Horned Frogs with 15 points.