Drew Smyly surrendered a season-high 10 hits and six runs in five frames for the Rays as he fell to 1-4 with a 3.63 ERA. Lee's three-run blast in the fourth gave Seattle a 6-2 lead, and the Mariners hung on to win for the 18th time in their past 25 games and maintain a 1 1/ 2-game lead over Texas in the American League West at 20-13.
Steve Cishek earned the four-out save for Seattle, coming on in the eighth to retire Souza on a sliding catch down the right-field line by Nelson Cruz to strand two runners.