Anderson, who won his second straight game and has a 3.26 ERA at Coors Field this season, allowed two hits and one run through the first six innings, but he found trouble in the seventh.
After issuing a leadoff walk, Tim Beckham, Luke Maile and pinch-hitter Nick Franklin each knocked extra-base hits off Anderson, ending his night with four earned runs over 6 1/3 innings. However, relievers Adam Ottavino, Jason Motte and Carlos Estevez combined to hold the Rays scoreless on one hit, and Estevez earned his sixth save of the season.