Week 11 featured arguably the best individual performance of the 2021 NFL season. Colts running back Jonathan Taylor ran for 185 yards and four touchdowns, and he added 19 more yards and a fifth score on three catches. Indianapolis pulled off the upset of the Bills, 41-15, behind Taylor's performance. The Vikings also upset the Packers on a final-play field goal, and receiver Justin Jefferson helped them get there with 169 receiving yards and a pair of TDs.
But perhaps the biggest upset of the week was the Texans' 22-13 victory over the Titans.