The Rays third baseman appeared to injure his thumb during the Indians' five-run fifth when Giovanny Urshela smoked a single off Longoria's glove.
Longoria grimaced after the play and clearly was uncomfortable, prompting a visit on the field from the Rays' trainer. After a brief examination, he remained in the game.
Longoria was replaced by Trevor Plouffe in the top of the sixth inning.
Bill Chastain has covered the Rays for MLB.com since 2004. This story was not subject to the approval of Major League Baseball or its clubs.