After scoring on Byron Buxton's sacrifice fly in the third, Suzuki took Smyly deep with his own dinger to left-center field in the fifth, extending the lead to 3-0.
Plouffe hit his second homer of the game in the sixth off Smyly, a two-run blast that easily cleared the boardwalk in left field and exited the park. An inning later, Suzuki hit a dinger off Jhan Marinez, making it 6-0.
Smyly pitched six innings, allowing five runs on five hits (three of them homers) with four strikeouts and one walk. The Twins' Opening Day starter Ervin Santana notched six scoreless innings, allowing three hits and no walks while striking out eight.