The Buccaneers are on a bit of a cold streak entering this week losing two straight to the New England Patriots and the Arizona Cardinals.
The offense looks out of sync and they might be without Jameis Winston.
While the Bills may not have the best roster on paper they are playing as a unit under a new regime with Sean McDermott.
They have the best scoring defense in the NFL and the seventh-ranked rush defense.
Their offense is a work in progress, but they have a big weapon with one of the best NFL running backs in LeSean McCoy.