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49ers WR Deebo Samuel carted off in first half vs. Buccaneers

SANTA CLARA, Calif. -- For the second week in a row, the San Francisco 49ers appeared to have suffered a significant injury to a key offensive player in the first half.

Receiver Deebo Samuel departed Sunday's game against the Tampa Bay Buccaneers with a left knee injury with about five minutes left in the second quarter. On second-and-9 at Tampa's 43, Samuel took a handoff from quarterback Brock Purdy and ran up the middle.

As a pair of Buccaneers defenders converged on Samuel, he attempted to spin out and appeared to get his left knee twisted in an awkward direction.