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Syracuse (5-5, 2-4 ACC) was held without a touchdown for the first time this season while host Louisville (5-5, 3-4 ACC) found the end zone on each of its first four possession in an eventual, 41-3 victory, for the Cards on Saturday.
Louisville quarterback Malik Campbell completed 13-of-18 passes for 209 yards and four touchdowns and ran seven times for 19 years and another touchdown.
Orange running back Sean Tucker surpassed 1,300 yards rushing on the season after carrying 19 times for 95 yards. Tucker passed Walter Reyes (1,347) on the Syracuse season rushing yards list and now trails only school record-holder Joe Morris (1,372).