Lucas Joao scored twice to continue Reading's positive start to the Championship campaign.
Paul Ince's side appear to have put last season's relegation form behind them and moved second in the table after they overcame Stoke here.
Lucas Joao rounded Stoke keeper Jack Bonham and finished from a tight angle inside the opening two minutes.
Ben Wilmot equalised for Alex Neil's Potters early in the second-half, finishing after Aden Flint had knocked the ball down to him.
But Wilmot was then villain as he fouled Joao for a penalty, which the Reading striker converted with confidence to secure another win.