Stoke City goalkeeper Adam Davies has been ruled out for four to eight weeks with a knee injury, further weakening Wales' stretched goalkeeping resources.
First-choice stopper Wayne Hennessey is already out until at least January with the injury the Crystal Palace player suffered against Bulgaria last month.
That leaves Leicester City's Danny Ward as Ryan Giggs' senior keeper choice.
Wales play the USA in a friendly on 12 November, before Nations League games with Republic of Ireland and Finland.
After facing the Americans at Swansea's Liberty Stadium, Wales host the Republic at Cardiff City Stadium on 15 November followed by the Finns at the same venue three days later.