From Stan Musial vs. Ernie Banks to Mark McGwire vs. Sammy Sosa, the storied rivalry between the St. Louis Cardinals and the Chicago Cubs spans generations and has had plenty of superstars on both sides. The Cubs hold the advantage all-time, with a record of 1,278-1,226 against the Cardinals, but in modern times, the Cardinals have found themselves on the winning end more often than not.
However, from 2014 to 2024, the Cubs had an ace up their sleeve that stymied the Cardinals seemingly every time they decided to utilize it. But finally, after a one-year stint away from Chicago, one of history's biggest Cardinals killers appears ready to put a bow on his career.