Pujols drilled a two-run homer in the third inning for the 699th of his career.
The crowd at Dodger Stadium cheered as if it was a hometown player, and once again on the road Pujols declined the invitation for a curtain call.
He is one homer shy of joining a club that has only three other members.
Pujols' 20th home run of the season came on two-strike fastball from Dodgers lefty Andrew Heaney and it gave the Cardinals a 2-0 lead in Friday night's game.