The fifth lead change of the game was the deciding one.
Bad for Louisiana baseball as it was on the other end of it as Southern Miss took a 10-9 lead in the bottom off the eighth inning off an RBI single from Chris Sargent. Reece Ewing tacked on a security run to bury the Ragin' Cajuns, 11-9, to take the series on Saturday in Hattiesburg.
Junior closer Justin Storm closed the door for USM in the ninth.
UL (36-20, 18-12 SBC) struck first, scoring four in the first inning, but regular-season Sun Belt Conference champion USM (37-16, 22-8) responded with a grand slam from Danny Lynch to tie things up.