Macklin, who recently became SIU's leading all-time scorer, would finish the game with three points and three rebounds.
The Dawgs hoped to give coach Cindy Stein her first road win against the Shockers as a birthday present, but couldn't overcome a slow start.
The Salukis (11-7, 4-2 Missouri Valley Conference) finished 1-20 from the 3-point line and shot 31 percent from the field.
Wichita State (4-14, 1-6 MVC) opened up the game on an 11-0 run and held the Salukis to only nine points in the first quarter.
In the second quarter, the Shockers continued their defensive dominance and forced seven turnovers.