The Salukis (20-13-1) were 11-22 with runners on base and 5-13 with runners in scoring position.
Senior Bryce Sablotny (3-3, 5.48 ERA) came away with the win, giving up two unearned runs and striking out five in 6 1/3 innings. Junior pitcher Chase Thurston (0-3 9.78 ERA) took the loss allowing six runs in 2 2/3 innings.
SIU scored four runs in the third, two in the sixth and four more in the seventh.
Sophomore second baseman Connor Kopach went 2-3 with four runs batted in and scored twice.
The Salukis begin a three-game series against Dallas Baptist at 6:30 p.