Southampton's Jack Stephens could be out for up to 12 weeks after injuring a tendon in his knee last weekend.
Stuart Armstrong remains out with a calf issue, while this match may come too soon for Theo Walcott, who is back in training after a minor injury.
Wolves defenders Yerson Mosquera and Rayan Ait-Nouri are both ruled out.
Mosquera made his first competitive appearance for the club in Wednesday's Carabao Cup game versus Tottenham, but was stretchered off after nine minutes with a hamstring injury.
Rayan Ait-Nouri was withdrawn after a clash of heads against Spurs and is unavailable because of concussion protocol.