Southampton winger Theo Walcott is unavailable because of an unspecified minor issue.
Midfielders Stuart Armstrong and Will Smallbone remain out, while forward Shane Long is isolating after a positive Covid-19 test.
West Ham have yet to make a change to their starting line-up this season but they can call upon new signings Kurt Zouma, Nikola Vlasic and Alex Kral.
Arthur Masuaku is training again after a knee injury and will be monitored.
LAWRO'S PREDICTION
Southampton are without a victory so far but I think their performances have been better than their results in their first three games.