Southampton may be able to welcome back Romain Perraud following a groin problem but Tino Livramento remains a long-term absentee.
Manchester United will have midfielder Casemiro available for selection after he received his work permit.
Victor Lindelof and Facundo Pellistri remain out, while Anthony Martial is in line for his first start of the season.
CHRIS SUTTON'S PREDICTION
I watched Southampton against Leicester last weekend. In the first half they had to weather a bit of pressure and then went behind to a James Maddison free-kick, but they responded brilliantly.
They ended up deservedly winning the game after Che Adams came off the bench and scored twice, and this won't be an easy one for Manchester United and boss Erik ten Hag.