Southampton remain without Danny Ings and Nathan Redmond because of respective knee and hamstring injuries.
Theo Walcott will continue playing despite having a broken bone in his left wrist.
Manchester United manager Ole Gunnar Solskjaer has said it is "very unlikely" that either Paul Pogba or Scott McTominay will be available.
Luke Shaw is still out but Marcus Rashford, Victor Lindelof and Aaron Wan-Bissaka should all be fit.
LAWRO'S PREDICTION
Manchester United have been much better on the road this season, winning three out of three away league games so far.
I am backing them to make it four out of four on Sunday, with the template being their win over Everton at Goodison Park before the international break.