Southampton pair Fraser Forster and Stuart Armstrong could be available this week, either for the visit of Liverpool or at Leicester on Sunday.
Both have been struggling with back and knee problems and only returned to training at the weekend.
Liverpool manager Jurgen Klopp will assess his squad's physical condition, with Mohamed Salah, Virgil van Dijk and Andy Robertson all forced off during the FA Cup final.
Fabinho is out with a muscle injury.
MATCH FACTS
Head-to-head
- Southampton have lost eight of the past nine league meetings, with the exception in that run being a 1-0 home victory in January 2021 courtesy of an early Danny Ings goal.