Southampton's leading goalscorer Danny Ings will miss Friday's game because of a thigh injury, with manager Ralph Hasenhuttl unsure whether the forward will play again this season.
Leicester winger Harvey Barnes has been ruled out for the rest of the season as he needs further knee surgery.
Club captain Wes Morgan is again ruled out by a back problem.
LAWRO'S PREDICTION
This is a re-run of the FA Cup semi-final from a couple of weeks ago and I think we will see the same outcome at St Mary's Stadium as we did at Wembley - a Leicester victory.