Manager Ralph Hassenhuttl has confirmed Lyanco is Southampton's only new injury concern, joining Tino Livramento on the sidelines.
Captain Liam Cooper and Adam Forshaw are also available.
Junior Firpo and Luke Ayling remain out, while Stuart Dallas has returned to light training but is not yet ready to play.
CHRIS SUTTON'S PREDICTION
Leeds got off to a good start by beating Wolves and they are one of my tips for relegation, which means they will probably win this week too.
Southampton got spanked by Tottenham last weekend after taking the lead.
Saints have gone to a back three after using it in pre-season, and although going to Spurs was a very difficult start to the season for them it is hard to tell how damaging that defeat will be.