Armel Bella-Kotchap will miss Southampton's final three games after being forced off with a hamstring injury against Nottingham Forest.
Romain Perraud, Mohamed Salisu, Juan Larios and Tino Livramento remain sidelined, while Che Adams is a doubt.
Saints will be relegated if they don't win, or if Nottingham Forest avoid defeat at Chelsea and Everton beat Manchester City on Sunday.
Aleksandar Mitrovic returns for Fulham after completing an eight-match ban.
Winger Daniel James missed Monday's win against Leicester because of a hamstring issue and is again unavailable, while Andreas Pereira, Tim Ream and Layvin Kurzawa are also ruled out.