Theo Walcott hopes to be fit despite coming off during Southampton's midweek EFL Cup win with a tight calf.
Full-back Kyle Walker-Peters played an hour in that game in his first action since suffering a hamstring injury in October, and is set to feature again.
Brighton's World Cup winner Alexis Mac Allister has been given a fortnight off after Argentina's triumph in Qatar.
Adam Webster and Danny Welbeck are both out after sustaining injuries in a friendly earlier this month.
MATCH FACTS
Head-to-head
- The home side has not won in any of the 10 Premier League meetings, with six draws and four away victories.