Southampton have no new injury concerns, although manager Claude Puel has said fatigue may be a factor in his team selection.
Charlie Austin is nearing a return after five months out with a dislocated shoulder, while Matt Targett could also feature before the end of the season.
Arsenal defender Laurent Koscielny is a doubt because of a calf injury.
Granit Xhaka should be available despite aggravating a similar problem against Manchester United.
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MOTD COMMENTATOR'S NOTES
Steve Wilson: "One swallow doesn't make a summer, but Arsenal's win over Manchester United on Sunday has given them a realistic shot at sneaking into fourth place and a Champions League qualification spot.