Sheffield United defender Phil Jagielka must serve a one-match ban.
Southampton trio Kyle Walker-Peters, Ibrahima Diallo and Takumi Minamino have all returned to training after recent injuries and are being assessed.
Moussa Djenepo may be rested to manage his workload in the wake of recent muscle injuries.
LAWRO'S PREDICTION
Southampton's freefall continued with their defeat against Everton on Monday and they have now taken just one point from nine matches.
This slump needs to stop soon if they are going to stay up, because the 30 points they have so far will not be enough for survival.