Coventry go into Saturday's game (12.30 GMT) having beaten Bristol City last weekend after a two-game winless run.
Only the Sky Blues (19) have taken more than Southampton's 18 points over the past eight Championship matches, although the Saints did suffer a 2-1 defeat by Norwich last Saturday.
Southampton have won three of their past four league games against Coventry (D1), as many as they had in their previous 18 (D9 L6).
Coventry have lost their past two away league games against Southampton, last losing three in a row between December 1970 and December 1972.