For the third successive Boxing Day Oxford United will have a different manager in charge from the one they started the season with after they sacked Gary Rowett on Tuesday.
Southampton are looking to avoid going three games without a league win for the third time this season.
This is the first league meeting between Oxford and Southampton since April 1988, and a goalless draw in the top-flight.
Southampton have won all four of their second-tier games against Oxford United, with these taking place between 1974 and 1976.