Blackburn are one of three sides in the Championship yet to win at home this season, with their last victory at Ewood Park coming in April.
Southampton's only away win so far came at Sheffield United at the end of September.
Blackburn Rovers have only won one of their past six league games against Southampton (D2 L3), failing to score in either league meeting in 2023-24.
Southampton have only won in one of their past 16 league visits to Blackburn Rovers (D4 L11), 2-0 in November 1998 with goals from Matt Oakley and Steve Basham.