Middlesbrough's head coach Steve Agnew is again likely to be without Daniel Ayala, Gaston Ramirez and Victor Valdes because of injury.
However, Adlene Guedioura is close to a first-team return after recovering from a groin strain.
Southampton boss Claude Puel may include striker Charlie Austin, who has been out since December with a dislocated shoulder.
Defender Matt Targett could also make his return after a long-term absence.
MOTD COMMENTATOR'S NOTES
John Roder: "Back in August, I was at the Riverside for Match of the Day for Middlesbrough's return to the Premier League.