Fulham head coach Scott Parker is self-isolating so his assistants Stuart Gray and Matt Wells will take charge.
On-loan midfielder Mario Lemina is also absent as he is ineligible against his parent club, while Terence Kongolo and Kenny Tete are doubts.
Defender Joachim Andersen is available after Fulham successfully appealed against last week's sending off.
Southampton will monitor injury doubts Danny Ings, Stuart Armstrong, Nathan Redmond and Jannik Vestergaard.
Midfielder Oriol Romeu is suspended so summer signing Ibrahima Diallo could make his first Premier League start.
MATCH FACTS
Head-to-head
- Fulham have lost just one of the seven Premier League meetings with Southampton at Craven Cottage, winning four and drawing twice.