Southampton can climb out of the drop zone with a win away at in-form Everton.
Mark Hughes' side ended a run of nine games without a victory against Bournemouth last weekend and they could make it back-to-back league wins for the first time in over a year.
However, they face a Toffees side who have 14 points from their last seven matches.
Sam Allardyce has faced criticism at Goodison Park for his style of play, but only the top five clubs have more points since he took over in November.