Cheick Doucoure is available for Crystal Palace after serving a one-match suspension for accumulating five yellow cards this season.
Ainsley Maitland-Niles returns for Southampton after being ineligible to face parent club Arsenal last weekend.
Romeo Lavia and Armel Bella-Kotchap are nearing full fitness but Kyle Walker-Peters is unlikely to return from injury until after the World Cup.
CHRIS SUTTON'S PREDICTION
Southampton are a team that I just can't work out. They were brilliant in the second half against Arsenal last week, but the Gunners could have been out of sight by then.
That's pretty typical of Saints though.